5-HT3 antagonist
Ondansetron
Zofran Antiemetic — salmon 2 mg/mL
Standard PONV prophylaxis, given at the end of surgery.
Typical adult doses
| Indication | Dose | Onset | Duration |
|---|---|---|---|
| PONV prophylaxis | 4 mg IV at end of surgery | — | — |
Mechanism
5-HT3 receptor antagonist (chemoreceptor trigger zone and vagal afferents).
Key effects
- Antiemetic
Watch out for
- QT prolongation
- Headache, constipation
Pimp questions
Pimp question
When is ondansetron given for PONV prophylaxis?
Answer
At the end of surgery (per consensus timing).