Analgesic / antipyretic
Acetaminophen IV
Ofirmev No ASTM class color (white) 10 mg/mL
Opioid-sparing analgesia; foundation of multimodal plans.
Typical adult doses
| Indication | Dose | Onset | Duration |
|---|---|---|---|
| Analgesia (≥ 50 kg) | 1 g IV every 6 h; max 4 g/day (lower with liver disease or alcohol use) | — | — |
Mechanism
Central COX inhibition and serotonergic pathways (not fully defined).
Key effects
- Analgesia, antipyresis
Watch out for
- Hepatotoxicity — count all sources (home meds, combination products)
Pimp questions
Pimp question
Why ask about home acetaminophen before giving 1 g IV?
Answer
To stay under the daily maximum and avoid hepatotoxicity.